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It is recommended to use the minimal effective dose and avoid continuous use to mitigate risks, such as potential tumor growth due to increased angiogenesis and upregulation of growth hormone receptors at injury sites 1 2

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Previous studies in other bacterial species, including Salmonella typhimurium ( 28 ) and Escherichia coli ( 29 ), showed that vitamin B12 repressed the expression of the cob/cbi operons in vitamin B12 biosynthesis pathway through cobalamin riboswitches