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Though the cause has not been clarified, the excess or inadequate release of maternal blood flow to the intervillous area has been linked to spontaneous and RPL to prevent miscarriage during the first trimester, several studies have been carried out using antioxidant supplements to restore depleted levels and counter an excessively oxidative environment

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This leads to a reduction in circulating LPS levels, thereby ameliorating LPS-induced systemic and hepatic inflammation, which in turn improves insulin signaling such as via the PI3K/AKT pathway and reduces insulin resistance, ultimately promoting better glucose uptake and lipid homeostasis [115]