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(Read more about research direction here.) Common Presentation / Symptoms of Lipedema Bilateral, symmetrical buildup of fat in the legs, and sometimes arms and lower trunk, that is resistant to nutritional intervention, exercise, elevation, diuretics, and bariatric surgery Feet/hands are typically spared, sometimes causing the appearance of an ankle or wrist “cuff” Almost exclusively affects women Complaints of pain, tenderness, heaviness in affected areas Fatigue Starts or worsens at times of hormonal changes: puberty, pregnancy, or menopause Easy bruising Presence of nodular and/or fibrotic texture beneath the skin that can create an uneven, dimpled appearance Edema and joint hypermobility may also be present Helpful Resources Among the resources throughout our website, the Lipedema Foundation maintains a Resources page where you will find everything from a Patient Self-Advocacy Guide to ICD Codes