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Worse, reperfusion itself can inflame the damage: a phenomenon known as cerebral ischemia/reperfusion injury (CIRI) accelerates neuronal death in the penumbra even after circulation returns

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A clinical trial demonstrated that 8 weeks of consecutive magnesium supplementation significantly increased sleep duration and reduced sleep latency in elderly individuals.10 In addition, magnesium treatment for patients with alcohol dependence (who often have magnesium metabolic disorders) using the PSQI significantly reduced the sleep onset latency, which decreased from an average of 40.6 min before treatment to 21.7 min ( P =0.03), and improved the subjective sleep quality.81 Interestingly, a study identified a negative correlation between magnesium intake and daytime sleepiness in women, but not in men