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Additionally, the flavonoids found in fruits and vegetables, such as quercetin and curcumin, have been shown to support detoxification by increasing the activity of detoxification enzymes, including those involved in conjugation

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Met-enkephalin secretagogue: DSIP triggers calcium-dependent, tetrodotoxin-insensitive release of the endogenous opioid Met-enkephalin from nerve endings, rather than binding opioid receptors directly