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The Vitamins+ formulation includes 250mg of ashwagandha (presumably Sensoril, as it's standardized to 10% withanolides) and 300mg of GABA — both of which are within clinical ranges.3 54 — along with 500mg of a "Deep Blue Mind Enhancing Blend” that comprises Rhodiola rosea and the fruiting-body extracts of three mushroom varieties: Cordyceps: Cordyceps mushrooms are abundant in the nucleoside adenosine, which can have positive effects on depression and anxiety.58 Reishi: A 2012 pilot clinical trial on breast cancer survivors found that reishi powder could improve anxiety and depression symptoms as well.38 Lion's mane: A four-week trial in 2010 found the possibility of similar outcomes with lion's mane mushrooms.39 Down the ingredient list, you'll find a secondary proprietary blend: 100mg of a "Wild-Crafted Blueberry Blend." Blueberries are rich in polyphenols, which one review in Brain, Behavior, and Immunity notes can be "beneficial to cognitive performance and mood."6 The last item listed on the label is dihydrohonokiol-B (DHH-B), a supplement with anxiolytic effects

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