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1.2.4 Tissue damage and pathological processes Long-term or severe hypoxia can trigger various tissue damages and pathological processes: Cellular Oxidative Stress: Cellular oxidative stress is a pathophysiological state in which the balance between intracellular oxidation and antioxidant action is upset in favor of the oxidative process, resulting in the abnormal accumulation of reactive oxygen species (ROS) such as superoxide anions (O2 ⁻), hydrogen peroxide (H₂O₂), hydroxyl radicals (OH⁻), etc

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doi: 10.4049/jimmunol.196.Supp.143.15 123 JoYShimJAJeongJWKimHLeeSMJeongJet al