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Moreover, PARK7/DJ-1 is capable of activating Akt [303, 304], suggesting that the mechanism by which PARK7/DJ-1 increases Nrf2-target gene expression most likely involves inhibition of formation of the DSGIS-containing phosphodegron and possibly not blocking of the interaction between Nrf2 and Keap1, as was suggested originally

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Ex vivo and in vivo experiments have demonstrated that CD44v6 CAR-T cells selectively eliminate AML cells while sparing HSCs but targeting monocytes (140)

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