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FIGURE 4 2.3 M2 macrophages and other immune cell involvement Crown-like structures have been observed in lipedema tissue ( + staining ( + , CD86 + M1, and CD206+ M2 macrophages all increased in population with increasing lipedema stage ( + M1 macrophages indicates an increase in inflammation as the disease progresses ( It has been specifically observed that lipedema is associated with a significant increase in M2 macrophage infiltration in lipedema tissue ( In contrast to the above studies, Straub et al., observed a suppression of inflammation and immune cell activation after performing transcriptomic analysis of abdominal and thigh subcutaneous adipose tissue of 14 lipedema patients ranging from stages 1–3 ( Other immune cells, such as T-cells and mast cells, have not been reported to be significantly different in lipedema tissue compared to healthy adipose tissue ( 2.4 Oxidative stress The impact of oxidative stress on lipedema has been explored

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Zhao Q , Li M , Chen M , et al