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The absence or overexpression of Piezo1 leads to abnormalities in the organism, such as hippocampal dysfunction (Xiong et al., 2022), cavernous cerebral malformation (Scimone et al., 2022), peritumoral brain edema (Qu et al., 2020a), and CNS demyelination (Velasco-Estevez et al., 2020)

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37 Patients may exhibit clinical features, such as abnormal growth of the hands, feet and facial features, and enlarged organs