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Consensus Statement on the definition and classification of metabolic hyperferritinaemia | Nature Reviews Endocrinology

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For example, when cultured in selenium-deficient conditions, Jurkat cells (a human T cell model) exhibit increased spontaneous cell death [18], due to decreased expression of selenium-dependent antioxidant enzymes (i.e., selenoproteins) such as glutathione peroxidases (GPx) and thioredoxin reductases leading to excessive oxidative stress and eventually cell death

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