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Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia

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Dendritic cell IL-23 production activates Th17 lymphocytes to produce IL-17A, IL-17F and IL-22, which in turn drive keratinocyte hyperplasia and the clinical appearance of well-demarcated, silver-scaled plaques