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Glucose-6-Phosphate Dehydrogenase Deficiency (which will be covered primarily in the hematology section) is a deficiency of a key enzyme in the pentose phosphate shunt that limits the creation of NADPH

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This underscores the necessity of investigating key regulatory factors, such as lactate, which profoundly influence macrophage polarization and immune modulation, thereby playing a pivotal role in tumor progression and therapy resistance