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Regarding mechanical components, tumor matrices are stiffer due to higher collagen production from stromal cells, and these collagen levels have been linked to Rho/ROCK and FAK regulation ( Unlike in the TME where angiogenesis is upregulated, some diseases are caused by or related to inhibited blood vessel growth, function, or survival

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[DOI] [PubMed] [Google Scholar] 34.Plášek J., Lazárová M., Dodulík J., Šulc P., Stejskal D., Švagera Z., Všianský F., Václavík J

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