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While they work to develop the full positive list, the FDA has finalized a guidance document that discusses an interim policy for active ingredients that are not a component of an FDA-approved drug and that do not have what the FDA considers to be an applicable USP monograph

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urinaria induces apoptosis in HepG2 cells in a concentration-dependent manner, displaying typical apoptotic characteristics like apoptotic bodies, cell shrinkage, membrane blebbing, and gelation