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but when the opacity is such as to exclude the light from the posterior part of the eye, which contains the third or vitreous humour, with the choroid coat, retina, and optic nerve, then the circular fibres relax, and the radiated fibres draw up the iris somewhat irregularly, which adhering to the capsule of the opaque lens, the pupil remains permanently open

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Similarly, patients on long-term therapy with various anticonvulsants (n=15) had a significantly lower urinary recovery of the sulfate conjugate and unchanged drug but a higher recovery of glucuronide metabolites of APAP relative to the healthy subjects (n=12) [72]