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Introduction Classically, since its discovery, isolation and administration to a pituitary dwarf ( in vivo , which may indicate that the nuclear GHR exerts functions that we do not yet know ( In any case, the supply of GH to cells or tissues needs an adequate blood flow, and the hormone plays a very important role in the formation of new blood vessels or the recovery of damaged vasculature ( In the case of gonadal function in females, it seems to be of interest that, to our knowledge, the first description of the existence of a strong immunoreactivity for the GH receptor at the nuclear level, was described in 1990 in rat oocytes (Figure 1)

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