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Studies in animals with medically induced kidney injury found that hydrangea extract significantly reduced BUN levels ( One of these studies also observed less kidney damage in mice treated with the extract, compared with a control group ( Another study similarly found that skimmin, an active molecule found in hydrangea extract, reduced BUN, blood creatinine, and urinary albumin excretion (UAE) in mice with kidney inflammation

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Your provider can assess whether your individual tolerance profile supports continuing injectable therapy, switching to oral formulations, or exploring compounded options with different carriers or concentrations